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Obesity, like other diseases, impairs the normal functioning of the body.

People who are obese have excess adipose (or fat) tissue that causes the overproduction of leptin (a molecule that regulates food intake and energy expenditure) and other food intake and energy mediators in the body, which leads to abnormal regulation of food intake and energy expenditure. [35] Obesity can impair normal mobility and range of motion in knees and hips, and obese patients make up 33% of all joint replacement operations. [48] Obesity is also linked to reproductive impairment, contributing to sexual dysfunction in both sexes, infertility and risk of miscarriage in women, and lower sperm counts in men. [48]

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